BRAND NAME:
Glusimet

GENERIC NAME:
Sitagliptin + Metformin (Fixed dose combination)

THERAPEUTIC SEGMENT:
Oral Anti diabetic

INDICATIONS:

Glusimet is a dipeptidyl peptidase-4 (DPP-4) inhibitor and biguanide combination product indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is appropriate.

BRIEF DESCRIPTION:
Glusimet contains a combination of metformin and sitagliptin. Metformin and sitagliptin are both oral diabetes medicines that help control blood sugar levels.

Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines.

Sitagliptin works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones released in response to a meal. By preventing GLP-1 and GIP inactivation, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreas. This drives blood glucose levels towards normal. As the blood glucose level approaches normal, the amounts of insulin released and glucagon suppressed diminishes, thus tending to prevent an "overshoot" and subsequent low blood sugar (hypoglycemia) which is seen with some other oral hypoglycemic agents.

DOSAGE FORM:
Tablet 50mg/500mg

Tablet 50mg/1000mg

PACK SIZE:
Tablet 50mg/500mg: 14's

Tablet 50mg/1000mg: 14's