Oral Anti diabetic
Glusit is indicated
as an adjunct to diet and exercise to improve glycemic control
in adults with type 2 diabetes mellitus.
Sitagliptin works to competitively inhibit
the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks
down the incretins GLP-1 and GIP, gastrointestinal hormones
released in response to a meal. By preventing GLP-1 and GIP
inactivation, they are able to increase the secretion of insulin
and suppress the release of glucagon by the alpha cells of
the pancreas. This drives blood glucose levels towards normal.
As the blood glucose level approaches normal, the amounts
of insulin released and glucagon suppressed diminishes, thus
tending to prevent an "overshoot" and subsequent
low blood sugar (hypoglycemia) which is seen with some other
oral hypoglycemic agents.