BRAND NAME:
Glusit

GENERIC NAME:
Sitagliptin

THERAPEUTIC SEGMENT:
Oral Anti diabetic

INDICATIONS:

Glusit is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

BRIEF DESCRIPTION:
Sitagliptin works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones released in response to a meal. By preventing GLP-1 and GIP inactivation, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreas. This drives blood glucose levels towards normal. As the blood glucose level approaches normal, the amounts of insulin released and glucagon suppressed diminishes, thus tending to prevent an "overshoot" and subsequent low blood sugar (hypoglycemia) which is seen with some other oral hypoglycemic agents.

DOSAGE FORM:
Tablet 50mg, 100mg

PACK SIZE:
Tablet 50mg: 14's

Tablet 100mg: 14's