BRAND NAME:
Tenovir

GENERIC NAME:
Tenofovir Disoproxil Fumarate

THERAPEUTIC SEGMENT:
Anti – Viral

INDICATIONS:
Tenovir is a nucleotide analog HIV-1 reverse transcriptase inhibitor and an HBV reverse transcriptase inhibitor and is indicated:
In combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older weighing at least 10 kg.
For the treatment of chronic hepatitis B in adults and pediatric patients 2 years and older weighing at least 10 kg.

BRIEF DESCRIPTION:
Tenofovir disoproxil fumarate is an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. Tenofovir disoproxil fumarate requires initial diester hydrolysis for conversion to tenofovir and subsequent phosphorylations by cellular enzymes to form tenofovir diphosphate (TFVDP), an obligate chain terminator. Tenofovir diphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) and HBV RT by competing with the natural substrate deoxyadenosine 5’¬ triphosphate and, after incorporation into DNA, by DNA chain termination. Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α, β, and mitochondrial DNA polymerase γ.

DOSAGE FORM:
Tablets
300mg

PACK SIZE:
30’s