Scilina-M XR
BRAND NAME:
Scilina-M XR
GENERIC NAME:
Empagliflozin + Linagliptin + Metformin HCl
THERAPEUTIC SEGMENT:
Antidiabetic
INDICATIONS:
Scilina-M XR is a combination of empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin hydrochloride (HCl), a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Empagliflozin is indicated to reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease.
BRIEF DESCRIPTION:
Empagliflozin + Linagliptin + Metformin XR is an orally bioavailable, triple-combination antidiabetic therapy that targets multiple pathophysiological pathways of type 2 diabetes mellitus (T2DM). Empagliflozin, a sodium-glucose co-transporter-2 (SGLT2) inhibitor, reduces renal glucose reabsorption, promoting glycosuria and improving glycemic control while also offering cardiovascular and renal benefits. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, enhances incretin hormone activity, increasing insulin secretion and reducing glucagon levels in a glucose-dependent manner. Metformin XR, a biguanide, decreases hepatic glucose production and improves insulin sensitivity. This combination provides complementary mechanisms for sustained glycemic control with a reduced risk of hypoglycemia.
DOSAGE FORM:
Tablets
5mg+2.5mg+1000mg
10mg+5mg+1000mg
12.5mg+2.5mg+1000mg
25mg+5mg+1000mg
Disclaimer: For use under medical prescription only
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