BRAND NAME:
Timer

GENERIC NAME:
Artemether + Lumefantrine

THERAPEUTIC SEGMENT:
Anti – Malarial

INDICATIONS:
Timer (Artemether / Lumefantrine) is indicated for the treatment of uncomplicated. P. falciparum malaria including multi-drug resistant strains of P. falciparum. Timer is also effective against the blood stage of P. vivax but not active against hypnozoites. Timer (Artemether / Lumefantrine) must be used for the malaria infections acquired in areas where the parasites may be resistant to other anti-malarial drugs. “World Health Organization recommends Artemether / Lumefantrine as a ¬first line treatment for the acute uncomplicated P. falciparum malaria for both multi-drug resistant areas & drug sensitive areas”.

BRIEF DESCRIPTION:
Both components Artemether / Lumefantrine have their own action site in the malarial parasite. The presence of the endoperoxide bridge in Artemether (generating single oxygen and free radicals, those are very cytotoxic to the plasmodia) appears to be essential for antimalarial activity. Morphological changes of the parasitic membranes induced by Artemether have been described, being the result of free-radical action.
Lumefantrine interferes more in the polymerization processes, other in vitro test suggest that both cause a marked diminution of nucleic acid synthesis Inhibition of protein synthesis as the basic mechanism of action is suggested in studies which showed morphological changes in ribosomes as well as in the endoplasmic reticulum. Although Artemether acts essentially as a blood schizonticide.

DOSAGE FORM:
Tablets
20mg+120mg, 80mg+480mg

PACK SIZE:
6’s